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乙型肝炎病毒(HBV)相关肝衰竭的发病机制迄今仍不够清楚,主要的进展有以下几点:(1)免疫学因素和非免疫学因素均起着重要作用;(2)现今特别强调病毒因素,这从核苷类似物抗病毒治疗所取得的满意疗效可以证明;(3)免疫抑制诱导的肝衰竭与免疫麻痹及病毒活跃复制有关;(4)宿主因素是导致慢性乙型肝炎呈现不同疾病表型及临床结局的主要因素。关于应用核苷类似物治疗HBV相关肝衰竭,主要有以下进展:(1)足够的证据显示,核苷类似物治疗乙型肝炎,包括暴
The pathogenesis of Hepatitis B virus (HBV) -related liver failure remains unclear until now. The main progresses are as follows: (1) both immunological and non-immunological factors play an important role; (2) the current emphasis on viruses Factors, which can be proved by the satisfactory curative effect of nucleoside analog anti-virus therapy; (3) immunosuppression-induced liver failure is related to immune paralysis and virus active replication; (4) host factor is the cause of chronic hepatitis B presents differently Disease phenotype and clinical outcome of the main factors. There are mainly the following advances regarding the use of nucleoside analogs for the treatment of HBV-related liver failure: (1) There is sufficient evidence that nucleoside analogues for the treatment of hepatitis B, including violence