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目的：探讨血浆神经肽Ｙ（ＮＰＹ）在急性脑出血中的作用及与血压的相关性。方法：用放射免疫分析法测定４３例急性脑出血患者和正常对照组２５例的血浆ＮＰＹ含量。结果：脑出血组血浆ＮＰＹ含量〔（８３．２２±１７．８７）ｎｇ／Ｌ〕高于正常对照组〔（７１．２４±１１．２３）ｎｇ／Ｌ〕，Ｐ＜０．０１；出血量＞５０ｍｌ者，血浆ＮＰＹ含量〔（９６．６４±１８．６９）ｎｇ／Ｌ〕高于出血量≤５０ｍｌ者〔（７８．７４±１５．３８）ｎｇ／Ｌ〕，Ｐ＜０．０１；随血浆ＮＰＹ含量增高而收缩压逐渐上升；血浆ＮＰＹ含量与收缩压呈正相关（ｒ＝０．８０８，Ｐ＜０．０１），３３例存活者血浆ＮＰＹ含量〔（７９．６８±１５．４９）ｎｇ／Ｌ〕低于１０例死亡者的血浆ＮＰＹ含量〔（９４．９１±２０．９８）ｎｇ／Ｌ〕，Ｐ＜０．０５。结论：脑出血患者血浆ＮＰＹ含量增高与血压呈正相关，故ＮＰＹ增高可作为脑出血患者的危险因素之一。因此，测定脑出血患者早期血浆ＮＰＹ含量对估计伤情和判断预后具有一定的帮助。
Objective: To investigate the role of plasma neuropeptide Y (NPY) in acute intracerebral hemorrhage and its relationship with blood pressure. Methods: Radioimmunoassay was used to determine plasma NPY levels in 43 patients with acute cerebral hemorrhage and 25 healthy controls. Results: The plasma levels of NPY in patients with intracerebral hemorrhage (83.22 ± 17.87 ng / L) were significantly higher than those in controls (71.24 ± 11.23 ng / L), P <0.01; > 50ml, the plasma NPY level 〔(96.64 ± 18.69) ng / L〕 was higher than that of the bleeding ≤50ml 〔(78.74 ± 15.38) ng / L〕, P <0.01; Plasma NPY levels increased while systolic blood pressure increased gradually. Plasma NPY levels were positively correlated with systolic blood pressure (r = 0.808, P <0.01). Plasma NPY levels in 33 survivors 〔(79.68 ± 15.49) ng / L], plasma NPY levels were less than 10 deaths 〔(94.91 ± 20.98) ng / L〕, P <0.05. Conclusion: There is a positive correlation between plasma NPY concentration and blood pressure in patients with intracerebral hemorrhage. Increasing NPY may be one of the risk factors in patients with intracerebral hemorrhage. Therefore, the determination of early plasma NPY levels in patients with cerebral hemorrhage may be helpful in estimating the injury and prognosis.