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目的探讨高血压患者应用降压与调脂药物联合治疗的效果及药学特点。方法 100例高血压患者,随机分为对照组及观察组,各50例。对照组单用降压药物治疗,观察组应用降压与调脂药物联合治疗。对比两组患者的治疗效果。结果治疗前,两组患者的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)指标比较,差异均无统计学意义(P>0.05);治疗后,两组患者的TC、TG、LDL-C指标较本组治疗前降低,HDL-C指标较本组治疗前升高,且观察组改善程度优于对照组,差异均具有统计学意义(P<0.05)。治疗前,两组患者收缩压(SBP)、舒张压(DBP)水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者SBP、DBP水平均较本组治疗前降低,且观察组SBP为(124.82±10.21)mmHg(1 mmHg=0.133 k Pa)、DBP为(85.56±7.15)mmHg,低于对照组的(136.32±10.98)、(90.17±9.22)mmHg,差异均具有统计学意义(P<0.05)。结论针对临床高血压患者,在应用降压药物常规治疗基础上,取调脂药物联合应用,可显著改善血脂和血压状况,具有非常积极的应用价值。
Objective To investigate the effect and pharmacological characteristics of combination therapy with antihypertensive and lipid-lowering drugs in hypertensive patients. Methods 100 cases of hypertensive patients were randomly divided into control group and observation group, 50 cases each. The control group was treated with antihypertensive drugs alone, and the observation group was treated with antihypertensive and lipid-lowering drugs. Compare the treatment effect of two groups of patients. Results Before treatment, there were no significant differences in TC, TG, HDL-C and LDL-C between the two groups (P> 0.05). After treatment, TC, TG and LDL-C in both groups were lower than before treatment, HDL-C index was higher than before treatment, and the improvement in observation group was better than that in control group , The differences were statistically significant (P <0.05). Before treatment, there was no significant difference in SBP and DBP between the two groups (P> 0.05). After treatment, the levels of SBP and DBP in both groups were lower than before treatment, The SBP in the observation group was (124.82 ± 10.21) mmHg (1 mmHg = 0.133 kPa) and DBP was (85.56 ± 7.15) mmHg, which was lower than that in the control group (136.32 ± 10.98) and (90.17 ± 9.22) mmHg, respectively Statistical significance (P <0.05). Conclusion For patients with clinical hypertension, based on the conventional treatment of antihypertensive drugs, the combination of lipid-lowering drugs can significantly improve blood lipids and blood pressure, which has a very positive value.