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观察吸烟的慢性支气管炎患者外周气道粘膜层内炎性细胞的特点。非吸烟对照组 12例 ,吸烟非慢支组 2 0例 ,吸烟并慢支组 2 8例 ,非吸烟慢支组 12例 ,手术取得的肺标本。应用免疫组化法检测外周气道粘膜层内CD3+ 、CD8+ 、CD6 8+ 、CD2 0 + 细胞 ,并与FEV1 0做相关性分析。吸烟并慢支组外周气道粘膜层内CD3+ 、CD8+ 细胞明显高于非吸烟对照组 (P <0 0 5 ) ,单纯吸烟组CD3+ 细胞数也明显高于非吸烟对照组。吸烟者CD3+ 、CD6 8+ 细胞与FEV1 0呈显著负相关。慢支患者吸烟组与非吸烟组相比无差异。吸烟并慢支患者外周气道以T淋巴细胞 ,尤其是CD8+ 细胞为主的炎症。
To observe the characteristics of inflammatory cells in the peripheral airway mucosa of patients with chronic bronchitis. Non-smoking control group of 12 cases, smoking non-chronic bronchitis group 20 cases, smoking and chronic bronchitis group 28 cases, 12 cases of non-smoking chronic bronchitis group, lung specimens obtained by surgery. The expression of CD3 +, CD8 +, CD6 +, CD20 + cells in the peripheral airway mucosa was detected by immunohistochemistry and correlation analysis with FEV10. The number of CD3 + and CD8 + cells in peripheral airway mucosa of smoking and chronic bronchitis group was significantly higher than that of non-smoking control group (P <0.05). The number of CD3 + cells in smoking group was also significantly higher than that in non-smoking control group. There was a significant negative correlation between cigarette smoke CD3 +, CD6 + cells and FEV10. There was no difference between smoking group and non-smoking group in patients with chronic bronchitis. Smoking and chronic bronchitis patients with peripheral T-lymphocytes, especially CD8 + cells-based inflammation.