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(下简称)系从放线菌Act.griseoruber var.beromycini var.nov.培养物分离而得的一种新的蒽环类抗肿瘤抗菌素。提取和分离:于pH7.0用丁醇提取,提取物通过硅胶柱,以氯仿洗涤后,用氯仿-甲醇(9∶1)洗脱,浓缩洗脱液以乙醚沉淀可得的干制品。经纸层析、薄层层析和逆流分溶分析,发现其中含有A,B,C三个组分。再经硅胶柱层析,以氯仿-苯-甲醇-丙酮(14∶7∶3∶4)系统展层,从氯仿-乙醇洗脱液可得B,C结晶。
(Hereinafter referred to as) is a new anthracycline anti-tumor antibiotic isolated from the culture of Act.griseoruber var. Beromycini var. Nov. Extraction and Separation: Extract with butanol at pH 7.0, extract through silica gel column, wash with chloroform, elute with chloroform-methanol (9: 1), concentrate the eluate and precipitate the resulting dry product in diethyl ether. After paper chromatography, thin layer chromatography and countercurrent dissolution analysis found that it contains A, B, C three components. Then silica gel column chromatography with chloroform - benzene - methanol - acetone (14: 7: 3: 4) system development, from chloroform - ethanol eluent available B, C crystallization.