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TNF-α与其受体结合后能引起炎症损伤,TNF-α抑制剂能有效地减轻炎症疾病的症状。本课题组此前已根据TNF-α受体的结构,自行设计并筛选出短肽抑制剂Pep 3,本实验通过Gal N/LPS腹腔内一次注射制备小鼠急性肝损伤模型,进一步评价其对于血清中TNF-α含量、肝组织抗氧化应激水平变化的影响。
TNF-α and its receptor can cause inflammation damage, TNF-α inhibitors can effectively reduce the symptoms of inflammatory diseases. Our group had previously designed and screened Pep 3, which is a short peptide inhibitor, according to the structure of TNF-α receptor. In this experiment, a mouse model of acute liver injury was prepared by intraperitoneal injection of Gal N / LPS and further evaluated its effect on serum TNF-α content, anti-oxidative stress in liver tissue.