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介绍了在卵巢癌的发展和治疗中表观遗传学的重要性,特别强调了在卵巢癌中内源性和获得性耐药性遗传途径中异常的DNA甲基化和组蛋白去乙酰化的重要性.通过表观遗传治疗反转肿瘤抑制基因沉寂和其他参与药物级联反应的基因沉寂为出现耐药性的卵巢癌患者带来了新的希望.
Introduced the importance of epigenetics in the development and treatment of ovarian cancer, with particular emphasis on the aberrant DNA methylation and histone deacetylation in endogenous and acquired drug resistant genetic pathways in ovarian cancer The importance of reversing the silence of tumor suppressor genes and other gene silencing involved in drug cascades through epigenetic therapy has brought new hope to patients with resistant ovarian cancers.