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应用免疫组化方法在含有肺鳞癌及其癌前病变的标本上观察了变异型CD44（CD44v）和增殖细胞核抗原（PC－NA）在肺鳞癌发生过程中出现表达的时间和频率。结果癌膏正常支气管上皮细胞未见CD44v表达，在鳞状化生的支气管上皮细胞、轻→中→重度不典型增生、原位癌、浸润癌，CD44v表达的阳性率逐渐升高，阳性细胞也逐渐增多。表达CD44v的不典型增生的支气管上皮，其相应的鳞癌CD44v也呈阳性表达。PCNA的表达也呈现上述特点，但出现表达的时间早于CD44v。结果表明，变异型CD44和PCNA可作为判断肿瘤发生可能性的有用的标记物，在肺鳞癌的早期诊断中具有重要意义。
The time and frequency of expression of variant CD44 (CD44v) and proliferating cell nuclear antigen (PC-NA) in the development of squamous cell carcinoma of the lung were observed by immunohistochemical staining on specimens containing lung squamous cell carcinoma and precancerous lesions. Results There was no expression of CD44v in normal bronchial epithelial cells. The positive rate of CD44v expression was gradually increased in squamous metaplastic bronchial epithelial cells, mild to moderate, severe dysplasia, carcinoma in situ, and invasive carcinoma. Gradually increased. The corresponding squamous cell carcinoma CD44v was also positively expressed in the bronchial epithelium of atypical hyperplasia expressing CD44v. PCNA expression also showed the above characteristics, but the expression appeared earlier than CD44v. The results show that the variant CD44 and PCNA can be useful markers for judging the possibility of tumorigenesis and have important significance in the early diagnosis of lung squamous cell carcinoma.