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1976年美国分离出首批产青霉素酶淋球菌菌株,并认为这些菌株是携带β—内酰胺酶基因的质粒的传递引起的。1980年以前,产青霉素酶淋球菌的感染数缓慢上升,而1980年之后其感染数明显增加。1985年产青霉素酶淋球菌的感染数为8720例,1988年呈进行性增加达38289例。80年代,美国产青霉素酶淋球菌(PPNG)
In 1976, the United States isolated the first strain of penicillinase-producing Neisseria gonorrhoeae and thought that these strains were caused by the transfer of the plasmid carrying the β-lactamase gene. Before 1980, the number of penicillinase-producing Neisseria gonorrhoeae infection increased slowly, but after 1980 the number of infections increased significantly. In 1985, the number of penicillin-producing Neisseria gonorrhoeae infection was 8720 cases, a progressive increase of 38289 cases in 1988. 80’s, the United States produced penicillinase Neisseria gonorrhoeae (PPNG)