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目的:观察五酯胶囊对移植受者他克莫司(Tacrolimus,Tac)血药浓度的影响,为他克莫司合理应用提供基础。方法:对接受肾移植并予以他克莫司为基础的免疫抑制治疗的患者进行回顾性分析,采用酶联免疫吸附法(ELISA法)监测合用五酯胶囊与否对患者他克莫司血药浓度的影响,记录他克莫司的给药剂量。分析性别、年龄对监测结果的影响。结果:观察组比对照组他克莫司用药剂量显著减少,血药浓度显著升高;同组患者合用后比与合用前比较,他克莫司血药浓度显著升高,提示可减少用药剂量;不同年龄段、性别未见明显差异。结论:五酯胶囊能升高他克莫司血药浓度谷值,五酯胶囊与他克莫司联合用药,能降低移植患者他克莫司的使用剂量。
OBJECTIVE: To observe the effect of Wuzhi Capsule on the plasma concentration of Tacrolimus (Tacrolimus) in transplant recipients, and provide the basis for the rational application of tacrolimus. Methods: Retrospective analysis was performed on patients receiving kidney transplantation and receiving tacrolimus-based immunosuppressive therapy. Enzyme-linked immunosorbent assay (ELISA) was used to monitor whether tacrolimus Concentration, record the dose of tacrolimus. Analysis of gender, age, the impact of monitoring results. Results: Compared with the control group, the dosage of tacrolimus was significantly decreased and the plasma concentration was significantly increased in the observation group. Compared with the pre-combination group, the tacrolimus plasma concentration was significantly increased, suggesting that the dosage of tacrolimus could be reduced ; Different age groups, no significant gender differences. Conclusion: Wuzhi Capsule can increase tacrolimus blood concentration valley, Wuzhi capsule combined with tacrolimus can reduce the dose of tacrolimus transplantation patients.