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目的:分析医院药房强化管理前后对促进合理使用抗菌药物措施的效果。方法:以医院药房抗菌药物的使用管理作为对象,将2014年1—12月间采用常规抗菌药物管理作为管理前组;将2015年1—12月间采用强化抗菌药物管理作为管理后组,在两组中各随机抽取2 000张抗菌药物处方进行相关指标的统计调查,分析两组不合理用药的概率、病原菌送检率等指标。结果:管理后组的不合理用药率为6.75%明显低于管理前组为12.10%(P<0.05);不合理用药原因主要为不明确指征用药以及给药方法、给药剂量、联合用药和药物选择不当;而在两组的抗菌药物使用上,管理后组的预防性用药比例、三联及以上联合用药比例和三级用药比例均低于前组(P<0.05);一级用药比例上升,且管理后组的病原菌送检率为27.05%明显高于管理前组为16.00%(P<0.05)。结论:医院药房管理工作中强化抗菌药物管理有助于降低不合理用药比例,提高了病原菌送检率和抗菌药物合理使用率。
Objective: To analyze the effect of promoting the rational use of antimicrobial agents before and after intensive management of hospital pharmacies. Methods: The use of antimicrobial drugs in the hospital pharmacies as the object, from January to December 2014 using conventional antimicrobial drug management as a management group; the use of intensive antimicrobial drug management from January to December 2015 as a management group, in the In each group, 2 000 prescriptions for antibiotics were randomly selected for statistical analysis of related indicators, and the probability of irrational use of drugs and the rate of pathogens in the two groups were analyzed. Results: The unreasonable drug use rate in the post-management group was 6.75%, which was significantly lower than that in the former management group (12.10%, P <0.05). The reasons for the unreasonable drug use were mainly the ambiguous indication medication and administration method, (P <0.05). In the two groups of antimicrobial use, the proportion of prophylactic drug administration, the combination of three or more drugs and the proportion of tertiary drug use were lower than the former group (P <0.05); the proportion of primary drug use , And the post-treatment rate of pathogens in the post-treatment group was 27.05%, which was significantly higher than that in the control group (16.00%, P <0.05). Conclusion: Strengthening the management of antimicrobial agents in hospital pharmacy management helps to reduce the proportion of unreasonable drug use, enhance the delivery rate of pathogens and rational use of antimicrobial agents.