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口腔托盘给药系统(DDDS)是在专业机械洁牙后用托盘局部输送药物的一种联合应用物理化学途径的口腔给药方法。DDDS由有储药池之称的个别托盘组成,贴附在牙体表面,借助于托盘的良好封闭作用,直接向牙体表面输送小剂量药物,使药物长时间保持有效的质量浓度,起到良好的治疗作用。通过DDDS给药,药物可长时间地保持有效质量浓度;减少口腔味觉改变、口腔烧灼感和细菌耐药情况的发生;用药灵活,可根据病情调整用药周期和药物配方;疗程可长可短,给药及移除药物方便。患者在家庭或办公时自行戴用托盘给药,减少了复诊次数,不会因复诊问题中断或延缓治疗。本文就DDDS托盘的制作,DDDS的使用,DDDS在牙体漂白中的应用、在治疗牙周病中的应用、在牙本质过敏治疗中的应用、在防龋中的应用等研究进展作一综述。
The oral tray delivery system (DDDS) is a combined oral and physio-logical approach to oral delivery of drugs using a tray after specialized mechanical teething. DDDS is composed of individual trays which are called medicinal reservoirs and is attached to the surface of the tooth body. Due to the good sealing function of the trays, the DDDS directly delivers small doses to the surface of the dental body so as to maintain the effective mass concentration for a long time Therapeutic effect. By DDDS administration, the drug can maintain an effective mass concentration for a long time; reduce the occurrence of oral taste changes, oral burning sensation and bacterial resistance; flexible medication can be adjusted according to the disease medication cycles and drug formulations; treatment can be long or short, Easy to administer and remove medications. Patients wearing their own pallets at home or at work will reduce the number of referrals and will not interrupt or delay treatment due to referral. In this paper, we review the research progress of the DDDS tray, the use of DDDS, the application of DDDS in tooth whitening, the application in the treatment of periodontal disease, the application in the treatment of dentin hypersensitivity, the application in the prevention of dental caries .