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本文研究了川芎嗪对大鼠慢性缺氧性肺动脉高压的预防及治疗效果。结果显示,川芎嗪经口服(100mg/kg)和腹腔注射(80mg/kg),每日二次,均可防止慢性缺氧性肺动脉高压及右心室肥大的发生。在已患慢性肺动脉高压的大鼠,静脉注射川芎嗪(80mg/kg)显著增加心输出量,降低肺血管阻力及肺动脉压力,其降压作用比正常及急性缺氧性肺动脉高压时更为明显。这提示川嗪芎可用于预防及治疗慢性缺氧性肺动脉高压及肺压病。
This article studies the prevention and treatment of tetrahydropyrazine on chronic hypoxic pulmonary hypertension in rats. The results showed that tetramethylpyrazine, administered orally (100 mg/kg) and intraperitoneally (80 mg/kg) twice daily, prevented the occurrence of chronic hypoxic pulmonary hypertension and right ventricular hypertrophy. In rats with chronic pulmonary hypertension, intravenous injection of tetramethylpyrazine (80mg/kg) significantly increased cardiac output, decreased pulmonary vascular resistance and pulmonary artery pressure, and its antihypertensive effect was more pronounced than normal and acute hypoxic pulmonary hypertension . This suggests that Chuanxiong may be used for the prevention and treatment of chronic hypoxic pulmonary hypertension and pulmonary hypertension.