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目的：了解强力宁的抗纤维化作用。方法：应用放免法和酶标法对所有研究对象进行前胶原Ⅲ肽（ＰⅢＰ）和透明质酸（ＨＡ）及Ⅳ胶原的检测，同时应用强力宁对部分慢性肝炎患者进行治疗，并随访８周。结果：慢性肝炎患者的ＰⅢＰ、ＨＡ及Ⅳ型胶原水平明显高于正常对照组（Ｐ＜０．０１）；肝组织纤维化程度与ＰⅢＰ、ＨＡ及Ⅳ型胶原水平有关系，以Ｓ３和Ｓ４期最高；强力宁治疗第６周时血清ＰⅢＰ水平下降（Ｐ＜０．０５），８周时，ＰⅢＰ、ＨＡ和Ⅳ型胶原水平均较治疗前低（Ｐ＜０．０５）。结论：肝纤维化时，血清ＰⅢＰ、ＨＡ及Ⅳ型胶原明显升高，３个指标的结合应用可作为肝纤维化早期诊断指标，强力宁有抑制肝纤维化的作用。
Objective: To understand the anti-fibrosis of Ning Ning. Methods: The radioimmunoassay and enzyme-linked immunosorbent assay were used to detect the procollagen III peptide (PⅢP), hyaluronic acid (HA) and collagen Ⅳ in all the patients. At the same time, we treated some patients with chronic hepatitis by glucocorticoids and were followed up for 8 weeks . Results: The levels of PⅢP, HA and type Ⅳ collagen in patients with chronic hepatitis were significantly higher than those in normal controls (P <0.01). The degree of liver fibrosis was related to the levels of PⅢP, HA and collagen Ⅳ. (P <0.05). At 8 weeks, the levels of PⅢP, HA and type Ⅳ collagen were lower than those before treatment (P <0.05). Conclusions: Serum PⅢP, HA and type Ⅳ collagen are obviously increased in liver fibrosis. The combination of three indexes can be used as early diagnosis index of liver fibrosis.