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脑内皮细胞(brain microvascular endothelial cell,BMEC)是一种高度分化,构成血脑屏障,具有在其它血管床未发现独特的生化和结构特征,是各种生理、病理因素作用的靶细胞。在实验研究和临床应用中,中药取得显著的成效,其具有上调细胞内氧化防御系统的活性,减少NO、氧自由基的产生,清除自由基,减少血脑屏障的渗透性,降低血管源性脑水肿,从而保护细胞免受氧化应激所伤,在脑水肿、脑肿瘤、脑缺血、糖尿病充当着重要的角色。
Brain microvascular endothelial cell (BMEC) is a kind of highly differentiated, blood-brain barrier. It has no unique biochemical and structural features in other vascular beds and is a target cell for various physiological and pathological factors. In experimental research and clinical application, Chinese medicine has achieved remarkable results. It has the effects of up-regulating the activity of intracellular oxidative defense system, reducing the production of NO and oxygen free radicals, scavenging free radicals, reducing the permeability of the blood-brain barrier, and decreasing the vasogenicity Brain edema, thereby protecting cells from oxidative stress injury, in brain edema, brain tumors, cerebral ischemia, diabetes plays an important role.