人乳头状病瘤病毒感染与宫颈癌及癌前病变关系的临床研究

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目的探讨HPV感染与宫颈癌前病变及宫颈癌的关系,为临床诊断和判断预后提供依据。方法回顾性分析2012-01-2016-04上海交通大学医学院附属瑞金医院90例宫颈癌、245例宫颈癌前病变、240例正常宫颈组织中HPV感染及型别分布状况共575例,年龄21~79(39±12)岁;研究对象为宫颈炎阴道镜下组织活检及同期所有子宫切除者并进行HPV DNA分型。结果慢性宫颈炎患者1种或多种高危型HPV(HR-HPV)感染率要低于宫颈上皮内瘤样病变(CIN)患者,宫颈癌HR-HPV感染率为98%;慢性宫颈炎患者低危型HPV(LR-HPV)感染率与CIN患者比较,差异无统计学意义。宫颈病变患者以单一HR-HPV亚型感染率更常见。结论宫颈癌及癌前病变与HPV感染密切相关。HPV感染是宫颈癌的主要致病因,HR-HPV基因检测及分型对宫颈病变的预后判断、疗效监测等方面具有重要价值。 Objective To investigate the relationship between HPV infection and cervical precancerous lesions and cervical cancer and provide the basis for clinical diagnosis and prognosis. Methods Retrospective analysis 2012-01-2016-04 There were 575 cases of HPV infection and type distribution in 90 cases of cervical cancer, 245 cases of cervical precancerous lesions and 240 cases of normal cervix in Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, age 21 ~ 79 (39 ± 12) years of age. Subjects were cervix colposcopy biopsies and all hysterectomies and HPV DNA typing. Results The infection rate of one or more high-risk HPV (HR-HPV) in patients with chronic cervicitis was lower than that in patients with cervical intraepithelial neoplasia (CIN). The infection rate of HR-HPV in cervical cancer was 98% There was no significant difference in the infection rate of LR-HPV among patients with CIN. Cervical lesions in patients with a single HR-HPV subtype infection rate is more common. Conclusion Cervical cancer and precancerous lesions are closely related to HPV infection. HPV infection is the main cause of cervical cancer, HR-HPV gene detection and classification of cervical lesions prognosis, efficacy monitoring has important value.
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