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目的：探讨儿童多发性抽动症的发病机制。方法：用荧光法和生化法测定患者血液多巴胺等单胺类神经递质的含量及钠钾ATP酶活性的变化。结果：多发性抽动症组多巴胺和去甲肾上腺素含量、钠钾ATP酶活性和5-羟色胺的转换率均显著高于正常对照组（P＜0．01）。结论：儿童多发性抽动症患者儿茶酚胺（主要是多巴胺）含量的高水平、5-羟色胺转换率的增高以及钠钾ATP酶活性的改变可能是多发性抽动症的发病机制之一。
Objective: To explore the pathogenesis of children with multiple tic disorder. Methods: Fluorescence and biochemical methods were used to determine the contents of monoamine neurotransmitters such as dopamine in blood and the changes of Na +, K + -ATPase activity. Results: The levels of dopamine and norepinephrine, sodium and potassium ATPase activity and serotonin conversion rate in patients with multiple tic disorder were significantly higher than those in the normal control group (P <0.01). CONCLUSIONS: High levels of catecholamines (mainly dopamine), increased serotonin conversion, and changes in sodium, potassium and potassium ATPase activity in children with TSS may be one of the pathogenesis of Tourette’s disease.