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5 (R) (l 艹孟 氧基 ) 2 (5H) 呋喃酮 (A)与苯甲醛肟 (B)进行 1 ,3 偶极环加成反应时得到两个产物 ,我们应用NOE及HMBC技术确证了它们的结构 .由于反应物 (A)的绝对构型已经X 射线单晶衍射法确证 ,因此通过NMR研究产物呋喃酮环上各手性碳的关系 ,最终确立产物的绝对构型 .
Two products were obtained by 1, 3 dipolar cycloaddition with furanone (A) and benzaldehyde oxime (B) from 5 (R) (1) menthoxy) 2 (5H) furanone and confirmed by NOE and HMBC Their structure was confirmed. Since the absolute configuration of the reactant (A) has been confirmed by X-ray single crystal diffraction, the relationship of each chiral carbon on the product furanone ring was studied by NMR to finally establish the absolute configuration of the product.