目的 观察碱性成纤维生长因子（bFGF）在视神经中的表达及在视神经损伤后的反应,探讨bFGF在视神经损伤中的作用。方法 采用大鼠球后视神经钳夹伤模型,利用免疫组化法和计算机图像分析技术,于术后1,3,7,14天检测视神经bFGF的表达。结果 视神经损伤后1-14天bFGF的表达明显增高,与假伤对照组相差显著（P<0.05）。结论 视神经损伤提高bFGF在视神经中的表达,对视神经损伤的修复具有积极的作用。 Objective To observe the expression of basic fibroblast growth factor (bFGF) in the optic nerve and the reaction after optic nerve injury, and to explore the role of bFGF in optic nerve injury. Methods The posterior optic nerve crush injury model was used in rats. The expression of bFGF in the optic nerve was detected by immunohistochemistry and computer image analysis at 1, 3, 7, and 14 days after operation. Results The expression of bFGF was significantly increased 1 to 14 days after optic nerve injury, which was significantly different from the control group (P <0.05). Conclusion The optic nerve injury increases the expression of bFGF in the optic nerve and plays a positive role in the repair of optic nerve injury.