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为探索鲨鱼肝再生因子(sHRF)对大鼠慢性酒精性肝损伤的保护作用,采用白酒灌胃法建立大鼠酒精性肝病模型,给药5周后取血清及肝组织测定各项肝指标,结果表明sHRF能显著降低酒精所致的大鼠血清ALT、AST的异常升高,也能抑制酒精损伤后大鼠肝组织中甘油三酯含量的升高,此外,sHRF能在一定程度上增加白蛋白含量,但对总蛋白含量无明显影响,sHRF给药治疗组还可明显提高SOD活性,降低MDA含量,提高大鼠清除体内氧自由基能力,减少过氧化脂质对组织器官的损伤,组织切片发现各给药组肝脏总体病变程度较模型组轻,说明sHRF对大鼠慢性酒精性肝损伤有一定的防护作用。
To explore the protective effect of shark liver regeneration factor (sHRF) on chronic alcoholic liver injury in rats, a model of alcoholic liver disease in rats was established by intragastric administration. Serum and liver tissues were measured after 5 weeks of administration. The results showed that sHRF could significantly reduce the abnormal increase of serum ALT and AST in rats induced by alcohol, and also inhibit the increase of triglyceride content in liver tissue of rats after alcohol injury. In addition, sHRF can increase white to a certain extent. Protein content, but no significant effect on the total protein content, sHRF treatment group can significantly increase SOD activity, reduce MDA content, improve the ability of rats to remove oxygen free radicals, reduce lipid peroxidation on tissues and organs, tissue The liver lesions in each administration group were found to be lighter than those in the model group, indicating that sHRF has a protective effect on chronic alcoholic liver injury in rats.