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神经胶质细胞瘤是最常见的原发性颅内肿瘤,其发病机制并不十分清楚。各种原癌基因与抑癌基因的突变或表达量的改变。BRAF基因,与神经胶质细胞瘤的发生密切相关。但BRAF表达量是否与神经胶质细胞瘤的恶性程度相关,未见相关报道,本研究在48例恶性程度不同的神经胶质细胞瘤中,通过免疫组织化学检测了BRAF基因的表达量改变。结果显示BRAF基因在恶性程度高的神经胶质细胞瘤中表达量较高,这提示我们BRAF基因的表达量可能可作为肿瘤恶性程度和预后的一个判断指标,也为干预BRAF基因表达,抑制神经胶质细胞瘤恶变提供了实验基础。
Glioblastoma is the most common primary intracranial tumor, the pathogenesis is not very clear. A variety of proto-oncogene and tumor suppressor gene mutations or changes in expression. BRAF gene is closely related to the occurrence of glioma. However, whether BRAF expression is related to the degree of malignancy of glioma, no relevant reports have been reported. In this study, the expression of BRAF gene was detected by immunohistochemistry in 48 malignant gliomas. The results showed that the expression of BRAF gene was higher in malignant gliomas, suggesting that the expression level of BRAF gene may be used as a judgment index of malignant degree and prognosis of tumor, as well as the intervention of BRAF gene expression and inhibition of nerve Glioblastoma provides experimental basis for malignant transformation.