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目的 探讨Bcl 2、C rasp2 1和增殖细胞核抗原 (PCNA)在卵巢上皮性肿瘤的表达及意义。方法 应用免疫组织化学ABC法对卵巢囊腺癌 6 0例、交界性囊腺瘤及良性囊腺瘤各 30例 ,进行Bcl 2、C rasp2 1和PCNA的检测。结果 Bcl 2、C rasp2 1在卵巢囊腺癌、交界性囊腺瘤及良性囊腺瘤的表达分别为 6 3 .3%和 81.5 %、37.0 %和 6 0 .6 %及 6 .6 %和 17.2 % ,三者之间差异具有显著性 (P <0 .0 1)。结论 检测C rasp2 1的表达率及PCNA的细胞增殖分数对判断卵巢囊腺瘤的良恶性及分级具有重要意义。C rasp2 1及PCNA表达强阳性者平均生存期较短 ,并与转移、扩散有关。Bcl - 2的表达与分化程度、预后有关 ,与转移、腹水形成无关
Objective To investigate the expression and significance of Bcl 2, C rasp2 1 and proliferating cell nuclear antigen (PCNA) in epithelial ovarian tumors. Methods 60 cases of ovarian cystadenocarcinoma, 30 cases of borderline cystadenoma and benign cystadenoma were immunohistochemically examined by ABC method. The expressions of Bcl 2, C rasp21 and PCNA were detected. Results The expressions of Bcl 2 and C rasp2 1 in ovarian cystadenocarcinoma, borderline cystadenoma and benign cystadenoma were 63.3% and 81.5%, 37.0% and 60.6% and 6.6%, respectively 17.2%, the difference between the three was significant (P <0.01). Conclusion The detection of C rasp2 1 expression and PCNA cell proliferation score of ovarian cystadenoma to determine the benign and malignant grade is of great significance. The average survival time of C rasp2 1 and PCNA with strong positive expression was short, and related to metastasis and spread. The expression of Bcl - 2 is related to the degree of differentiation and prognosis, but not to the metastasis and the formation of ascites