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该文将壳寡糖应用于黄芩苷复合物的制备,以提高药物的体外溶出度,考察复合物的基本性质。采用溶剂法制备黄芩苷壳寡糖复合物,运用差示扫描量热法(DSC)、扫描电镜法(SEM)、X-射线粉末衍射法(XRD)和红外振动光谱(IR)等分析方法对其结构和理化性质进行了分析,并考察其溶出行为。实验结果显示黄芩苷-壳寡糖摩尔比1:1制备的复合物能显著提高黄芩苷的溶出度。DSC和XRD分析结果显示黄芩苷以非晶形态存在,IR结果表明壳寡糖与黄芩苷之间存在相互作用。黄芩苷-壳寡糖复合物能够显著提高药物的体外溶出度。
In this paper, chitooligosaccharides were applied to the preparation of baicalin complexes in order to improve the drug dissolution in vitro, to investigate the basic properties of the complex. The baicalin chitooligosaccharides complex was prepared by solvent method and analyzed by differential scanning calorimetry (DSC), scanning electron microscopy (SEM), X-ray powder diffraction (XRD) and infrared vibrational spectroscopy Its structure and physicochemical properties were analyzed and its dissolution behavior was investigated. The experimental results show that baicalin - chitosan molar ratio of 1: 1 prepared complex can significantly improve the baicalin dissolution. DSC and XRD results showed that baicalin exists in amorphous form and the IR results show that there is interaction between chitosan and baicalin. Baicalin - chitosan oligosaccharide complex can significantly improve the drug dissolution in vitro.