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目的 探讨内皮素 (ET)、一氧化氮 (NO)在小儿原发性肾病综合征 (PNS)中的变化及相互关系。方法 用放射免疫分析法和分光光度法分别检测PNS患儿血、尿ET和NO水平 ,并与正常对照组进行比较 ;用直线相关分析法对血ET分别与血NO、尿ET、尿NO、血白蛋白、尿蛋白及血NO分别与尿NO、尿ET、血白蛋白、尿蛋白等进行比较。结果 PNS患儿极期血、尿ET均明显高于对照组 (P均 <0 .0 1) ,缓解期下降 ,与对照组比较无显著差异 ;血、尿NO在极期也均非常明显高于对照组 (P均 <0 .0 1) ,缓解期亦下降 ,与对照组比较无显著差异 ;血ET与血NO、尿EF、尿NO、血白蛋白、尿蛋白均无相关性 ;血NO与尿NO呈显著正相关 (r =0 .4 99,P <0 .0 5 ) ,与尿ET、血白蛋白、尿蛋白均无相关性。结论 ET、NO均参与PNS发病过程
Objective To investigate the changes and correlations of endothelin (ET) and nitric oxide (NO) in children with primary nephrotic syndrome (PNS). Methods The levels of blood and urine ET and NO in children with PNS were measured by radioimmunoassay and spectrophotometry respectively and compared with the normal control group. The levels of blood ET, urinary ET, urinary NO, Serum albumin, urinary protein and blood NO were compared with urine NO, urinary ET, serum albumin, urine protein and so on. Results The levels of ET and ET in the PNS group were significantly higher than those in the control group (all P <0.01), and the remission period was not significantly different between the two groups. The levels of NO and NO in the PNS group were also significantly higher than those in the control group There was no significant difference between the control group and the control group (P <0.01), and there was no significant difference between the two groups in the remission stage. There was no correlation between ET and serum NO, urinary EF, urinary NO, serum albumin and urine protein There was a significant positive correlation between NO and urinary NO (r = 0.999, P <0.05), but no correlation with urinary ET, serum albumin and urine protein. Conclusion Both ET and NO are involved in the pathogenesis of PNS