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色甘酸钠(SCG)1968年用于治疗哮喘,其作用机理是稳定肥大细胞膜从而抑制致喘介质的释放。Altoungan 等于1965年以天然植物色原酮凯刺素(Khellin)为原料合成 SCG.凯刺素具有舒张平滑肌的作用,曾用于肠绞痛,因怀疑会引起胃肠不适,故一直未得到广泛应用。Altoungan 等通过实验以改善凯刺素舒张平滑肌的能力,消除其副作用,从而找到治疗哮喘独特的新药。
Sodium cromoglycate (SCG) was used to treat asthma in 1968 and its mechanism of action is to stabilize the mast cell membrane and thereby inhibit the release of the asthmatic medium. Altoungan is equivalent to the natural plant chromogen Khellin synthesis of SCG in 1965. Kaythrins have the role of relaxation of the smooth muscle, had used for colic, because of suspicion of causing gastrointestinal discomfort, it has not been widely application. Altoungan and others through experiments to improve the ability of kaschin to relax smooth muscle, eliminating its side effects, to find a unique new drug for the treatment of asthma.