Trimetallic palladium-copper-cobalt nanoparticles supported on reduced graphene oxide (PdCuCo/RGO) with different molar ratios of Pd, Cu and Co can be synthesized by facile chemical reduction with NaBH 4 as reductant and cetrimonium bromide as stabilizer. The morphology, structure and composition of the as-synthesized catalysts are characterized by transmission electron microscopy, X-ray diffraction and X- ray photoelectron spectroscopy. The cyclic voltammetry and chronoamperometry are utilized to inves- tigate the electrochemical activities and stabilities of the as-obtained catalysts. The results demonstrate that the PdCuCo/RGO catalyst shows superior catalytic activity and stability for methanol electrooxidation in alkaline media compared with PdCu/RGO, PdCo/RGO, and Pd/RGO catalysts. These findings suggest that the PdCuCo/RGO catalyst possesses a great potential as a promising anode catalyst for direct methanol fuel cells.