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免疫化疗复合物抗体曾用以将药物、毒素、酶、放射同位素和硼等运送到特定组织部位,尤其用于治癌。应用肿瘤特异性抗体与药物的复合物,可使效能更高、耐受更好,其协同机理可能是:(1)抗体分子使药物局限于靶组织;(2)使复合物中的一种组分(如药物)的抗瘤活性受另一种(如抗体)所加强;(3)抗体促使药物透入细胞内起作用;(4)由于复合物缓慢释放或降解,起到延效作用(库存作用);(5)因与抗体相互作用,使经过细胞周
Immunochemotherapy Complex Antibodies have been used to deliver drugs, toxins, enzymes, radioisotopes and boron to specific tissue sites, especially for cancer. The use of a combination of tumor-specific antibodies and drugs results in higher potency and better tolerability. The synergistic mechanism may be: (1) the antibody molecule confines the drug to the target tissue; (2) one of the complexes The anti-tumor activity of a component, such as a drug, is enhanced by another, such as an antibody; (3) the antibody causes the drug to penetrate into the cell to function; and (4) a delay effect due to slow release or degradation of the complex (Stock effect); (5) due to the interaction with the antibody, so that the cell cycle