对复方甲硝唑嗽口液的改型剂———复方甲硝唑含片进行安全限度动物实验。方法为采用一次灌胃法 ,测定复方甲硝唑含片在小鼠体内的最大耐受量 ;并采取口腔涂抹法进行局部粘膜刺激试验。结果为最大耐受量大于 440mg/kg,口腔及咽部粘膜刺激反应值为 0。结论 :其最大耐受量相当于临床人用量的 550倍 ,且局部粘膜无刺激性 ,本品含服毒性很小 ,安全范围大。 Compound metronidazole rinse mouth remover - Compound metronidazole tablets for safety limits of animal experiments. Method for the use of a gavage method to determine the maximum tolerated dose of compound metronidazole tablets in mice; and local oral mucosal stimulation test. The results for the maximum tolerated dose is greater than 440mg / kg, oral and pharyngeal mucosal irritation response value of 0. Conclusion: The maximum tolerated dose is equivalent to 550 times the clinical dosage, and no irritation of the local mucosa, this product contains little toxicity, safety range.