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对３４例妊娠合并系统性红斑狼疮（ＳＬＥ）患者（ＳＬＥ组）的胎盘作病理研究，并与２３例正常妊娠妇女（对照组）进行对照。结果发现：ＳＬＥ组胎盘重量明显低于对照组（Ｐ＜０．０５），胎盘系数两组间差异无显著性。对ＳＬＥ组中１８例作组织计量分析得出：ＳＬＥ组胎盘绒毛面积比小于对照组（Ｐ＜０．０１）。扫描电镜观察所见：绒毛外观纤细、分枝较少，末梢绒毛呈豆芽状，绒毛表面有多个针尖样小孔，还可见到崩裂团块。免疫组化研究提示：绒毛血管壁上可见到ＩｇＧ、ＩｇＡ、ＩｇＭ、Ｃ＿３沉积。提示ＳＬＥ孕妇的胎盘受到免疫复合物的损伤。
The placenta of 34 pregnant women with systemic lupus erythematosus (SLE) were studied by pathology and compared with 23 normal pregnant women (control group). The results showed that the weight of placenta in SLE group was significantly lower than that in control group (P <0.05), and there was no significant difference in placental coefficient between the two groups. Eighteen cases in SLE group were measured by histological analysis. The results showed that the placental area ratio in SLE group was smaller than that in control group (P <0.01). Scanning electron microscopy showed that the appearance of the villi was slender with fewer branches, sprouts of the terminal sprouts and multiple needle-like holes on the surface of the villi. Cracked clumps could also be seen. Immunohistochemical studies suggest that: IgG, IgA, IgM, C_3 deposition can be seen on the villus wall. Prompt SLE pregnant women placenta immune complexes damage.