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目的观察尼莫地平联合天麻素胶囊对偏头痛患者的疗效观察及血清C反应蛋白(CRP)、一氧化氮(NO)的影响。方法 90例偏头痛患者随机分为尼莫地平组、天麻素组、联合治疗组各30例,疗程15d,比较各组的临床治疗效果。收集各组患者治疗前后静脉血,测定各组血清CRP、NO的变化。结果联合治疗组的总有效率均高于尼莫地平组及天麻素组(P<0.05),尼莫地平组与天麻素组相比,差异无统计学意义(P>0.05),经治疗后,各组患者血清CRP、NO的含量下降(P<0.05),联合治疗组更为明显(P<0.05)。结论尼莫地平联合天麻素胶囊治疗偏头痛具有较好的临床疗效,可降低患者血清CRP、NO含量。
Objective To observe the effect of nimodipine and gastrodin capsules on migraine patients and the effects of serum C-reactive protein (CRP) and nitric oxide (NO). Methods 90 migraineurs were randomly divided into nimodipine group, gastrodin group and combination therapy group, 30 cases each for 15 days. The clinical effect of each group was compared. Venous blood was collected before and after treatment in each group, and the changes of serum CRP and NO were measured. Results The total effective rate in combination therapy group was higher than that in nimodipine group and gastrodin group (P <0.05). There was no significant difference between nimodipine group and gastrodin group (P> 0.05) The levels of serum CRP and NO in all groups decreased (P <0.05), and the combination therapy group was more obvious (P <0.05). Conclusion The combination of nimodipine and gastrodin capsules in the treatment of migraine has good clinical curative effect, which can reduce the serum levels of CRP and NO.