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目的评价射频消融术在原发性小肝癌治疗中的应用效果。方法纳入原发性小肝癌患者96例,均在CT引导下实施射频消融术,进一步对手术疗效进行分析评价。结果肿瘤直径<2.5 cm组缓解率与完全缓解率与其他两组相比,差异具有统计学意义(P<0.05)。治疗后与治疗前相比,患者的AFP水平差异有统计学意义(t=8.593,P<0.05)。经30 d随诊,无患者有肝功能恶化情况发生。经随访,由于肝功能衰竭、肝功能恶化或并发其他脏器衰竭等原因死亡共8例,总病死率为8.33%。出现并发症5例,发生率为5.21%。结论对于原发性小肝癌患者,实施射频消融术治疗有显著疗效,此术式操作简单、创伤少、术后并发症低、恢复速度快;因此,值得在临床治疗中采纳应用。
Objective To evaluate the effect of radiofrequency ablation in the treatment of primary small hepatocellular carcinoma. Methods Ninety-six patients with primary small hepatocellular carcinoma (HCC) were enrolled in this study. Radiofrequency catheter ablation was performed under CT guidance to further evaluate the efficacy of the surgery. Results The remission rate and complete remission rate of tumor diameter <2.5 cm group were significantly different from the other two groups (P <0.05). After treatment, the level of AFP in the patients before treatment was significantly different (t = 8.593, P <0.05). After 30 d follow-up, no patient had deterioration of liver function. After follow-up, there were 8 deaths due to liver failure, worsening liver function or other organ failure, with a total case fatality rate of 8.33%. Complications occurred in 5 cases, the incidence was 5.21%. Conclusion For the patients with primary small hepatocellular carcinoma, the radiofrequency ablation has a significant curative effect. The operation is simple, less traumatic, low postoperative complications and rapid recovery; therefore, it is worth to be applied in clinical treatment.