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1例27岁男性因服用含有西布曲明的减肥药，2个月后出现发热、肌痛症状。2 d后症状加重，出现意识不清、皮疹和尿少，血肌酐748 μmol/L，天冬氨酸转氨酶299 U/L，丙氨酸转氨酶102 U/L，总胆红素101.6 μmol/L，直接胆红素85.5 μmol/L，乳酸脱氢酶3 070 U/L，肌红蛋白12 081 μg/L，肌酸激酶18 517 U/L。诊断为西布曲明引起的横纹肌溶解，合并多系统损伤。停用减肥药，给予连续性肾脏替代治疗，同时给予异甘草酸镁、乙酰半胱氨酸、特利加压素等对症支持治疗。2周后，患者症状消失，皮疹完全消退，肝、肾功能及肌酸激酶、肌红蛋白等实验室检查结果均恢复正常。“,”A 27-year-old male patient mistakenly took an anti-obesity agent containing sibutramine. Two months later, the patient developed fever and myalgia. Two days later, his above symptoms were aggravated, and unconsciousness, rashes, and oliguria appeared. Laboratory tests showed serum creatinine 748 μmol/L, aspartate aminotransferase 299 U/L, alanine aminotransferase 102 U/L, total bilirubin 101.6 μmol/L, direct bilirubin 85.5 μmol/L, lactate dehydrogenase 3 070 U/L, myoglobin 12 081 μg/L, and creatine kinase 18 517 U/L. Rhabdomyolysis with multisystem injury caused by sibutramine was diagnosed. The anti-obesity agent was discontinued, and continuous renal replacement therapy and symptomatic and supportive treatments such as magnesium isoglycyrrhizinate, acetylcysteine, and terlipressin were given. After 2 weeks, the patient′s symptoms disappeared, the rashes subsided, and the liver and kidney functions and laboratory tests such as creatine kinase and myoglobin returned to normal.