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已正式批准使用的乙型肝炎(乙肝)疫苗,包括早期的血源疫苗和目前普遍使用的重组疫苗,按常规方案实施一个免疫程序后确有一定比例的接种者表面抗体(抗-HBs)滴度不能达到保护水平(即10 IU/L),在健康人群中该比例波动在2%~15%之间。这些所谓无应答者对乙肝病毒(HBV)仍然易感,一旦感染仍可发病或成为病毒携带者。乙肝疫苗接种无应答是个体内、外部多种因素共同作用的结果,内部
Hepatitis B (HB) vaccines, which have been officially approved for use, include early blood-borne vaccines and recombinant vaccines currently in widespread use, and a certain percentage of vaccinated human antibodies (anti-HBs) are indeed dropped after an immunization program is routinely administered Degree can not reach the level of protection (ie 10 IU / L), the proportion of fluctuations in the healthy population between 2% to 15%. These so-called non-responders are still susceptible to hepatitis B virus (HBV) and can still develop or become virus carriers once infected. Hepatitis B vaccination non-response is a combination of many internal and external factors, the internal