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目的从红树植物内生真菌中寻找具有酶抑制活性的次生代谢产物。方法利用各种柱层析手段,结合各种波谱方法分离鉴定红树植物内生真菌GT6105的化学成分。结果从红树植物内生真菌GT6105发酵液中分离纯化了12个化合物邻苯二甲酸二乙基己酯(1),阿魏酸(2),3,5-二羟基甲苯(3),邻苯二甲酸丁酯(4),2-羟基-3-苯丙酸(5),2,3-二羟基甲苯(6),3,4,5-三羟基甲苯(7),5-甲氧基-2,3-二羟基甲苯(8),对羟基苯甲酸(9),2,2-二甲基-1-苯并吡喃-6-醇(10),2,2-二甲基-6-羧基-苯并吡喃(11),4-(4-甲酰-2-甲氧-1-苯氧基)丁酸(12)。结论化合物12为首次从天然界分得,化合物2、10和11具有较弱的酶抑制活性。
Objective To search for secondary metabolites with enzyme inhibitory activity from mangrove endophytic fungi. Methods The chemical constituents of GT6105, an endophytic fungus of mangrove plant, were isolated and identified by various column chromatographic methods. Results Twelve compounds diethyl hexyl phthalate (1), ferulic acid (2), 3,5-dihydroxytoluene (3) were isolated and purified from mangrove endophytic fungi GT6105 fermentation broth. Butylene phthalate (4), 2-hydroxy-3-phenylpropionic acid (5), 2,3-dihydroxytoluene (6), 3,4,5-trihydroxytoluene (7), 5-methoxy -2,3-dihydroxytoluene (8), p-hydroxybenzoic acid (9), 2,2-dimethyl-1-benzopyran-6-ol (10), 2,2-dimethyl -6-Carboxy-benzopyran (11), 4-(4-Formyl-2-methoxy-1-phenoxy)butyric acid (12). Conclusion Compound 12 was isolated from the natural world for the first time. Compounds 2, 10 and 11 had weak enzyme inhibitory activity.