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目的观察地塞米松溶液局部滴耳对防治中耳胆脂瘤术后复发的临床疗效。方法 30例中耳胆脂瘤患者,施行开放式鼓室成形术后1月,非随机法分为2组:治疗组15例,局部应用地塞米松溶液和氧氟沙星滴耳液的混合溶液,每日2～3次,连续使用6～12月,对照组15例局部不使用任何滴耳液,仅门诊定期清理外耳道分泌物;所有患者定期门诊随诊至术后2年,根据症状及耳内镜检查结果评价两组患者的治疗效果。结果治疗组和对照组分别有12例和13例按要求完成定期随访,依据症状和耳内镜检查结果,两组中耳乳突胆脂瘤局部复发的例数为分别为2例和5例,治疗组胆脂瘤的复发率16.7%明显低于对照组的38.5%。结论局部应用地塞米松溶液对防治中耳胆脂瘤术后病变复发有较好的效果。
Objective To observe the clinical efficacy of dexamethasone solution local ear drop on the prevention and treatment of middle ear cholesteatoma recurrence. Methods Thirty patients with middle ear cholesteatoma undergoing open tympanoplasty were randomly divided into two groups: treatment group (n = 15), topical dexamethasone solution and ofloxacin ear drops mixed solution , 2 to 3 times a day, continuous use of 6 to 12 months, the control group of 15 cases did not use any ear drops ear drops, outpatient clinic regularly clean the external auditory canal secretions; all patients were outpatient clinic to 2 years after surgery, according to the symptoms and Ear endoscopy results to evaluate the treatment effect of two groups of patients. Results The treatment group and the control group were 12 cases and 13 cases were completed on follow-up on a regular basis. According to the symptoms and endoscopic findings, the number of cases of local recurrence of middle ear and ear cholesteatoma were 2 cases and 5 cases respectively The recurrence rate of cholesteatoma in treatment group was significantly lower than that in control group (16.7% vs 38.5%). Conclusion Topical application of dexamethasone solution for prevention and treatment of middle ear cholesteatoma postoperative disease recurrence has a good effect.