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目的:研究配体结构对NAMI衍生物的水解、溶液稳定性的影响。方法:制备了化合物1 trans-[RuCl4(DMSO)(ni-ca)]Na.2DMSO(nica,nicotinamide烟酰胺);用紫外分光光度法研究了化合物1的水解机制,动力学及溶液稳定性。结果:与NAMI相似,化合物1在pH 7.40的缓冲液中发生2步脱氯水解反应(Ⅰ氯水解及Ⅱ氯水解);在pH 5.00缓冲液中二甲基亚砜(DM-SO)水解。测定了各水解反应表观速率常数、半衰期及溶液稳定性参数。结论:化合物1在酸性溶液中的稳定性明显高于中性溶液。用烟酰胺取代咪唑环能够明显减慢NAMI衍生物的脱氯水解反应速度,但对脱DMSO水解反应影响较小。
Objective: To study the effect of ligand structure on the hydrolysis and solution stability of NAMI derivatives. Methods: Compound 1 trans- [RuCl4 (DMSO) (ni-ca)] Na.2DMSO (nica, nicotinamide nicotinamide) was prepared. The hydrolysis mechanism, kinetics and solution stability of compound 1 were studied by UV spectrophotometry. Results: Similar to NAMI, Compound 1 undergoes two steps of dechlorination hydrolysis (I and II) in pH 7.40 buffer; hydrolysis of dimethylsulfoxide (DM-SO) in pH 5.00 buffer. The apparent rate constants, half-lives and solution stability parameters of each hydrolysis reaction were determined. Conclusion: The stability of compound 1 in acidic solution is obviously higher than that in neutral solution. Replacing the imidazole ring with nicotinamide can slow down the rate of dechlorination hydrolysis of NAMI derivatives, but have little effect on the hydrolysis of DMSO.