纤溶系统是通过纤溶酶原活化剂(PA)将纤溶酶原转变为纤溶酶而起作用的。有两种不同的内生性PA,一为尿激酶样PA(u-PA),一为组织型PA(t-PA)。以前曾表明唾液具有抗纤溶活性。本研究是为了进一步确定人唾液的抗纤溶活性的特征和测定它对游离的t-PA和u-PA的直接作用。 材料和方法 唾液来自23位健康志愿者,年龄25～50岁。混合的新鲜的人唾液(MFHS)一部分经离心后分离出上清液和沉淀的细胞团。另一部分MFHS用 The fibrinolytic system acts by converting plasminogen to plasmin through plasminogen activator (PA). There are two different endogenous PA, urokinase-like PA (u-PA), a tissue-type PA (t-PA). Saliva has previously been shown to have anti-fibrinolytic activity. This study was designed to further characterize the anti-fibrinolytic activity of human saliva and to determine its direct effect on free t-PA and u-PA. Materials and Methods Saliva from 23 healthy volunteers, aged 25 to 50 years. A portion of the mixed fresh human saliva (MFHS) is centrifuged to separate the supernatant and pelleted cells. Another part of MFHS use