硒,一个重要的超微量元素,在谷胱甘肽代谢和抗癌与抗突变中起着重要的作用。硒化合物通常被认为比相应的硫与碲类似物有更强的生物活性。作者曾报道一类新的烷化剂——氮芥的有机硒类似物的化学动力学参数和细胞毒性。这些对位取代芳基2 Selenium, an important trace element, plays an important role in glutathione metabolism and anti-cancer and anti-mutation. Selenium compounds are generally considered to be more bioactive than the corresponding sulfur and tellurium analogs. The authors have reported the chemical kinetic parameters and cytotoxicity of a new class of alkylating agents, nitrogen-mustard organic selenium analogues. These para-substituted aryl 2