为揭示上鼓室内陷是否发展成胆脂瘤,本文对鼓膜病理变化进行了前瞻性研究。作者对分泌性中耳炎治疗后随访观察上鼓室内陷和鼓膜紧张部病理变化,指出重度内陷是直接发展成胆脂瘤的基础。作者从1977年至1978年,通过耳显微镜检查、鼓室压测量、听力测验等对3～8年前治疗的278例(527耳)分泌性中耳炎儿童进行了 In order to reveal whether the upper tympanic cavity is evolved into cholesteatoma, we prospectively studied the pathological changes of the tympanic membrane. After the treatment of secretory otitis media, the authors observed the tympanic cavity invagination and tympanic membrane tension and pathology changes, pointed out that severe invagination is the direct basis for the development of cholesteatoma. From 1977 to 1978, 278 cases (527 ears) of secretory otitis media children treated 3 to 8 years ago underwent ear microscopy, tympanometry, audiometry, etc.