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原发性高血压和各种高血压的发生,以前认为主要是与肾素-血管紧张素-醛固酮系统和交感神经系统等升压系统有关,稍后,又发现与血管舒缓素(Kallikrein)-激肽(Kinin)系统等降压系统亦有关系。最近的研究表明,前列腺素E与高血压亦有很大的关系,它是一种血管减压物质,有显著的扩张血管作用,可能是由肾脏髓质的间质细胞产生,从肾小管的髓袢升支分泌于尿中。由尿中测出的前列腺素E水平,可作为肾分泌前列腺素E的情况的指标。千叶等用放射免疫的方法,准确地测定尿前列腺素E,发现:原发性高血压和原发性醛固酮增多症的患者尿中前列腺素E,较之血压正常人明显地减少,说明,肾分泌前列腺素E减
Primary hypertension and a variety of high blood pressure, previously thought to be mainly associated with the renin-angiotensin-aldosterone system and the sympathetic nervous system and other vasopressors, was later found to be associated with kallikrein- Kinin system and other antihypertensive system is also related. Recent studies have shown that prostaglandin E also has a great relationship with hypertension, it is a vasopressor substance, a significant dilation of blood vessels, may be produced by the interstitial cells of the renal medulla, from the tubules Medullary ascending branch secreted in the urine. Prostaglandin E levels measured in urine can be used as an indicator of renal secretion of prostaglandin E. Chiba and other methods of radioimmunoassay, accurate determination of urinary prostaglandin E, found: primary hypertension and primary aldosteronism in patients with urinary prostaglandin E, significantly lower than normal blood pressure, indicating that, Kidney secretion of prostaglandin E minus