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目的探讨乌司他丁对急性重症胰腺炎患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平及肝肾功能的影响。方法选取开封市第一人民医院2009年1月至2013年6月320例重症急性胰腺炎患者,根据自愿原则分为研究组和对照组,对照组予以常规性治疗,研究组应用乌司他丁治疗,分析对比两组患者治疗效果。结果研究组治疗总有效率为95.00%,与对照组(70.00%)比较,差异有统计学意义;经治疗,两组血清IL-6、TNF-α、肝肾功能指标比较差异有统计学意义(P<0.05)。结论乌司他丁对急性胰腺炎具有明显的治疗效果,可以调控机体炎症反应,避免炎症发展,缓解胰腺炎临床症状,确保患者快速痊愈。
Objective To investigate the effects of ulinastatin on serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and liver and kidney function in patients with severe acute pancreatitis. Methods The First People’s Hospital of Kaifeng from January 2009 to June 2013, 320 cases of severe acute pancreatitis were divided into study group and control group according to the voluntary principle, while the control group was given routine treatment. The study group was given ulinastatin Treatment, analysis and comparison of two groups of patients treatment effect. Results The total effective rate of the study group was 95.00%, which was significantly different from that of the control group (70.00%). After treatment, the serum IL-6, TNF-α, liver and kidney function indexes were significantly different (P <0.05). Conclusion Ulinastatin has a significant therapeutic effect on acute pancreatitis, which can regulate the inflammatory response, prevent the development of inflammation, relieve the clinical symptoms of pancreatitis and ensure the rapid recovery of patients.