论文部分内容阅读
为了解ＫＲａｓ癌基因表达产物Ｐ２１蛋白质与子宫内膜癌产生和发展的关系，用免疫组织化学ＳＰ染色法对４８例子宫内膜癌、２０例子宫内膜增殖症和２０例正常子宫内膜组织进行检测。３５例子宫内膜癌组织Ｐ２１蛋白质表达阳性（阳性率为７２９％）；２０例子宫内膜增殖症和２０例正常子宫内膜组织Ｐ２１蛋白质表达阴性。Ｐ２１蛋白质表达随癌组织病理分级和侵肌程度上升增强。ＫＲａｓ癌基因产物Ｐ２１蛋白质的表达与子宫内膜癌的发生、发展和预后有关，对指导临床治疗有意义。
In order to understand the relationship between KRas oncogene P21 protein expression and the development of endometrial cancer, 48 cases of endometrial carcinoma, 20 cases of endometrial hyperplasia and 20 cases of normal uterus Membrane tissue testing. 35 cases of endometrial cancer P21 protein expression was positive (positive rate was 72 9%); 20 cases of endometrial hyperplasia and 20 cases of normal endometrial tissue P21 protein expression was negative. The expression of P21 protein increased with the histopathological grade and invasion of cancer. K Ras oncogene product P21 protein expression and the occurrence, development and prognosis of endometrial cancer, the guidance of clinical treatment is meaningful.