作者总结了迄今使用的两大类杀红内期裂殖体药物—抗叶酸药和亲溶酶体药,认为由于抗药性的广泛出现,多种药物在未来的抗疟治疗中的前景暗淡。需要研制作用机制不同以往的新药。亚临床实验是研制新药必须的步骤。在进入亚临床实验前,应先明确一个药物作用靶,并依次解决下列问题:1)作用 The authors summarize the two major classes of anti-midazolam schizonts used so far, antifolate and lysosomal drugs, and suggest that prospects for various antimalarial treatments for various drugs will dim in the future due to the emergence of drug resistance. Need to develop new mechanisms of action different from the past. Subclinical experiments are the necessary steps to develop new drugs. Before entering the subclinical experiment, you should first clear a drug target, and in turn solve the following problems: 1) role