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最近Zoumbos及其同事报告,再生障碍性贫血(再障)患者血循环中激活的抑制性T细胞(Ts)增加.在12例患者中,约7%的外周血淋巴细胞同时表达CD8和HLA-DR抗原,而多次输血的对照组为2.5%.在CD8~+细胞中,约有1/3表达IL-2受体,而对照组仅为2%.在宿主防御系统重度抑制的患者血循环中存在激活的Ts细胞并不令人惊奇,重要的是该论文提示这些细胞参与了骨髓衰竭的形成.在3例患者
Recently Zoumbos and colleagues report an increase in circulating activated inhibitory T cells (Ts) in the circulation of patients with aplastic anemia (aplastic anemia), and about 7% of peripheral blood lymphocytes express both CD8 and HLA-DR Antigen and multiple blood transfusion in the control group was 2.5% .In CD8 ~ + cells, about 1/3 expressed IL-2 receptor, while the control group was only 2% in patients with severe suppression of the host defense system in the blood circulation It is not surprising that activated Ts cells are present, and it is important that the paper suggests that these cells are involved in the development of bone marrow failure.In 3 patients