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目的：探讨维生素E（VitE）和人参茎叶皂甙（GSL）对高脂血症小鼠血脂的影响。方法：用胆固醇乳剂灌胃小鼠10d，建立小鼠高脂血症模型，观察用VitE和人参茎叶甙后小鼠血脂水平的变化。结果：高脂模型组血清总胆固醇（TC）、甘油三酯（TG）升高，高密度脂蛋白胆固醇（HDL－C）降低，与对照组比较，差异有显著性，表明模型建立成功。与模型组比较，VitE可降低TG，升高HDL－C，而不降低TC。人参茎叶甙则只降低TC，升高HDL-C，而不降低TG。结论：VitE和人参茎叶皂甙对高脂血症小鼠均有一定降脂作用。
Objective: To investigate the effects of vitamin E (VitE) and ginseng stem and leaf saponin (GSL) on the blood lipid of mice with hyperlipidemia. Methods: The mice were injected intraperitoneally with cholesterol emulsion for 10 days to establish the mouse model of hyperlipidemia. The changes of blood lipid levels in mice after VitE and ginseng stem and leaf glycosides were observed. Results: The levels of total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) in high fat model group were significantly lower than those in control group, indicating that the model was established successfully. Compared with model group, VitE decreased TG and increased HDL-C, but did not lower TC. Ginseng stems and leaves glycosides only lower TC, increase HDL-C, without reducing TG. Conclusion: VitE and ginseng stems and leaves saponin have a certain lipid-lowering effect on mice with hyperlipidemia.