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目的:探讨加味葛根芩连汤联合西药治疗小儿手足口病疗效观察及对心肌酶的影响。方法:78例手足口病患儿按照随机数字表法随机分为观察组和对照组。对照组采用西药治疗,观察组在对照组基础上结合加味葛根芩连汤治疗。两组患儿均以3 d为1个疗程,连续服用两个疗程后评价疗效、心肌酶水平变化,临床症状消退时间及治疗过程中不良反应发生情况。结果:观察组总有效率(94.87%)显著高于对照组(74.36%),且具有统计学差异(P<0.05);治疗后观察组患儿乳酸脱氢酶和肌磷酸激酶水平明显低于对照组,且有统计学意义(P<0.05);观察组口腔溃疡愈合时间、热退时间、疱疹消失时间均显著短于对照组,且具有统计学意义(P<0.05);治疗过程中两组患儿均未发生明显不良反应。结论:加味葛根芩连汤联合西药治疗小儿手足口病疗效显著,可改善患儿临床症状且加快其消退时间,降低心肌酶水平,具有重要临床研究意义。
Objective: To investigate the curative effect of flavored Gegen Qinlian Decoction combined with Western medicine in children with hand-foot-mouth disease and its effect on myocardial enzymes. Methods: 78 HFMD children were randomly divided into observation group and control group according to random number table method. The control group was treated with western medicine, and the observation group was treated with flavored Gegen Qinlian Decoction on the basis of the control group. Two groups of children were 3 d for a course of treatment, continuous treatment of two courses after the evaluation of efficacy, changes in myocardial enzyme levels, clinical symptoms subsided time and adverse reactions during treatment. Results: The total effective rate (94.87%) in the observation group was significantly higher than that in the control group (74.36%) (P <0.05), and the levels of lactate dehydrogenase and phosphokinase in the observation group were significantly lower than those in the observation group (P <0.05). The healing time, thermal back time and disappearance time of herpetic ulcer in the observation group were significantly shorter than those in the control group (P <0.05). During the treatment, No significant adverse reactions occurred in children. Conclusion: Modified Gegen Qinlian Decoction combined with Western medicine treatment of children with hand foot and mouth disease has significant effect, can improve clinical symptoms and accelerate the subsided time, reduce myocardial enzyme levels, has important clinical significance.