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目的:观察不同给药途径对阿芙唑嗪(Alf)和多沙唑嗪(Dox)降尿道压的选择性作用,方法:电刺激麻醉猫腹下神经以升高尿道压。比较十二指肠和静脉两种途径给药时,Alf和Dox降低平均动脉血压(MBP)及尿道压(UP)的作用,结果:相同电刺激条件下(10 Hz,25 V),Alf肠道给药与静脉给药时ED_(20)(BP))/ED_(50)(UP))比值为10.9:4.3;Dox两种给药途径的比值为3.1:2.1,Alf十二指肠给药降尿道压作用的选择性优于静脉给药,Dox两种给药途径的作用无显著性差异,结论:Alf胃肠道给药时,选择性降低电刺激诱发的尿道压升高,而Dox无此特点,Alf对尿道的选择性作用与药物生物利用度和生物转化的种属差异无关。
OBJECTIVE: To observe the selective effects of different routes of administration on the urethral pressure reduction by alfacalcid (Alf) and doxazosin (Dox). Methods: Electrical stimulation of the cat’s abdominal nerve was used to raise the urethral pressure. Alf and Dox reduced mean arterial blood pressure (MBP) and urethral pressure (UP) when compared with administration of duodenum and vein. Results: Under the same electrical stimulation (10 Hz, 25 V), Alf intestinal The ratio of ED_ (20) (BP) / ED_ (50) (UP)) was 10.9: 4.3 for both administration and administration of Dox. The ratio of Dox to the two routes of administration was 3.1: 2.1. The effect of lowering drug pressure on urinary tract pressure was superior to that of intravenous injection. There was no significant difference between the two routes of administration of Dox. Conclusion: Alf gastrointestinal tract selectively reduced the urinary tract pressure induced by electrical stimulation, while Dox did not have this feature, Alf selective effects on the urethra and drug bioavailability and biological transformation of the species has nothing to do.