本文报道用荧光分光光度法测定脱镁叶绿三酸在S_(180)腹水瘤荷瘤小鼠体内的分布及肿瘤组织与不同组织间的分布比。静注20mg/kg的脱镁叶绿三酸6h后,不同组织中的药物浓度均达峰值。药后24h,药物在肿瘤与皮肤及骨骼肌之间的分布差距最大,肿瘤/皮肤和肿瘤/骨骼肌分布比分别为19和34。实验结果表明脱镁叶绿三酸是一种具有发展前途的新型肿瘤光化学诊治剂。 In this paper, fluorescence spectrophotometry was used to determine the distribution of pheophorbide in the tumor-bearing mice with S 180 ascitic tumors and the distribution ratio between tumor tissues and different tissues. After intravenous injection of 20 mg/kg pheophorbide for 6 h, the drug concentrations in different tissues reached a peak. At 24 h after drug administration, the distribution of the drug between tumor and skin and skeletal muscles was the largest, and the tumor/skin and tumor/skeletal muscle distribution ratios were 19 and 34, respectively. The experimental results show that pheophorbide is a new type of tumor photochemical diagnosis and treatment agent with promising development.