1961年 Smith 用化学方法首先合成了环胞苷酸(cGMP),但直到1974年,Bloch 才从L_(1210)白血病细胞中提取成功,证明它确系细胞内的组成成份,还发现外源性的 cGMP 能刺激 L_(1210)细胞的增殖。随后 Gech,Bloch 及 Kuo 等分别进行了 cGMP 环化酶和磷酸二酯酶的提取及其在组织中含量方面的研究,初步探讨了 cGMP 在细胞内的生理功能。1978年 Gailla报道了测定 cGMP 的放射免疫方法,为进一步研究 cGMP 在细胞内的作用机制提供了较灵敏的测定方法。目前虽然有关研究 cGMP 的文章还很少,但是上述作者的研究成果,已为进一步研究 cGMP 奠定了良好的基础。 In 1961, Smith chemically synthesized cGMP first, but it was not until 1974 that Bloch successfully extracted from L 1210 leukemia cells that it was indeed a cellular component and found exogenous CGMP stimulates the proliferation of L 1210 cells. Subsequently Gech, Bloch and Kuo, respectively, were cGMP cyclase and phosphodiesterase extraction and its content in the tissue studies cGMP preliminary study of physiological functions in the cell. In 1978, Gailla reported the radioimmunoassay for measuring cGMP, which provided a more sensitive method for further studying the mechanism of action of cGMP in cells. Although there are still few articles on cGMP research, the research results of the above authors have laid a good foundation for further study of cGMP.