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目的观察枪弹噪声对大鼠胃粘膜的急性损伤作用并探讨与某些激素的关系。方法采用32只国标Wistar大鼠,以56式冲锋枪射击时产生的脉冲噪声,对大鼠连续进行声刺激,随机分设实验A,B,C组(分别刺激1,12,24h)及对照组(不行声刺激,其他条件相同)。分别观察胃粘膜损伤情况及某些激素变化。结果各实验组胃粘膜损伤指数显著高于对照组(P<0.01);光镜、电镜观察组织学变化也有显著区别;血清促胃液素(Gas)及血浆内皮素(ET)均显著高于对照组(P<0.05),血浆一氧化氮(NO)显著低于对照组(P<0.05)。结论枪弹噪声对大鼠胃粘膜有急性损伤作用;Gas,ET,NO在其发病机制中均起到十分重要作用,此对战地防治胃疾病具有指导意义。
Objective To observe the effect of bullet noise on acute gastric mucosal injury in rats and explore its relationship with some hormones. Methods Thirty-two Wistar rats were randomly divided into experimental groups A, B and C (stimulated 1, 12 and 24 hours respectively) and control group No sound stimulation, other conditions the same). Gastric mucosal damage were observed and some changes in hormones. Results The gastric mucosal injury index of each experimental group was significantly higher than that of the control group (P <0.01). There was also a significant difference between the experimental group and the control group (P <0.01). The levels of serum gastrin and plasma endothelin (ET) Group (P <0.05), and the level of plasma nitric oxide (NO) was significantly lower than that of the control group (P <0.05). Conclusion Gunshot noises have an acute injury on gastric mucosa in rats. Gas, ET and NO all play important roles in the pathogenesis of gastric mucosa.